Correction of fluorescence bias on Affymetrix genotyping microarrays

Ralph Rippe, JJ Meulman, Paul Eilers

Research output: Contribution to journalArticleAcademicpeer-review


Fluorescence signals obtained from microarrays for single nucleotide polymorphism genotyping show systematic strong variations in the levels for single nucleotide polymorphisms and arrays as well as genotypes. Linear models that take all three effects into account fit very well. Once the model parameters have been estimated for a set of reference arrays, they can be used to calibrate new arrays in a simple way, thereby improving genotyping and analysis of copy number variations and allelic imbalance. Copyright (c) 2012 John Wiley & Sons, Ltd.
Original languageUndefined/Unknown
Pages (from-to)191-196
Number of pages6
JournalJournal of Chemometrics
Issue number5
Publication statusPublished - 2012

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