Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia

MJ (Maarten) van den Berg, Anne Huisman, Patricia Bemt, H Den Breeijen, TCG (Toine) Egberts, WW van Solinge

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Context: A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment. Objective: We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients. Materials and methods: Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia. Results and conclusions: We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.
Original languageUndefined/Unknown
Pages (from-to)51-57
Number of pages7
JournalBiomarkers
Volume16
Issue number1
DOIs
Publication statusPublished - 2011

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