DNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation

Gerarda van de Kamp, Tim Heemskerk, Roland Kanaar, Jeroen Essers*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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The superior dose distribution of particle radiation compared to photon radiation makes it a promising therapy for the treatment of tumors. However, the cellular responses to particle therapy and especially the DNA damage response (DDR) is not well characterized. Compared to photons, particles are thought to induce more closely spaced DNA lesions instead of isolated lesions. How this different spatial configuration of the DNA damage directs DNA repair pathway usage, is subject of current investigations. In this review, we describe recent insights into induction of DNA damage by particle radiation and how this shapes DNA end processing and subsequent DNA repair mechanisms. Additionally, we give an overview of promising DDR targets to improve particle therapy.

Original languageEnglish
Article number738230
JournalFrontiers in Genetics
Publication statusPublished - 30 Sept 2021

Bibliographical note

Funding Information:
This work was supported by the Dutch Cancer Society (INTO-PROT, 12092/2018) and Varian (PROTON-DDR, 2019020), and is part of the Oncode Institute, which was partly financed by the Dutch Cancer Society.

Publisher Copyright:
© Copyright © 2021 van de Kamp, Heemskerk, Kanaar and Essers.


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