Major Adverse Cardiac Events and the Severity of Coronary Atherosclerosis Assessed by Computed Tomography Coronary Angiography in an Outpatient Population With Suspected or Known Coronary Artery Disease

A Aldrovandi, E Maffei, S Seitun, C Martini, E Berti, R Grilli, G Messalli, A.C. Weustink, Nico Mollet, Koen Nieman, D Ardissino, Pim Feijter, Gabriel Krestin, F. Cademartiri

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Purpose: To investigate the predictive value of 64-slice computed tomography coronary angiography (CTCA) for major adverse cardiac events (MACEs) in patients with suspected or known coronary artery disease (CAD). Materials and Methods: Seven hundred and sixty-seven consecutive patients (496 men, age 62 +/- 11 y) with suspected or known heart disease referred to an outpatient clinic underwent 64-slice CTCA. The patients were followed for the occurrence of MACE (ie, cardiac death, nonfatal myocardial infarction, unstable angina). Results: Eleven thousand five hundred and sixty-four coronary segments were assessed. Of these, 178 (1.5%) were not assessable because of insufficient image quality. Overall, CTCA revealed the absence of CAD in 219 (28.5%) patients, nonobstructive CAD (coronary plaque <= 50%) in 282 (36.8%) patients, and obstructive CAD in 266 (34.7%) patients. A total of 21 major cardiac events (4 cardiac deaths, 12 myocardial infarctions, and 5 unstable angina) occurred during a mean follow-up of 20 months. On Conclusions: Coronary plaque evaluation by CTCA provides an independent prognostic value for the prediction of MACE. Patients with normal CTCA findings have an excellent prognosis at follow-up.
Original languageUndefined/Unknown
Pages (from-to)23-28
Number of pages6
JournalJournal of Thoracic Imaging
Issue number1
Publication statusPublished - 2012

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