Male Sexual Health and Reproduction in Cutaneous Immune-Mediated Diseases: A Systematic Review

Luis F. Perez-Garcia*, Radboud Dolhain, Bernke te Winkel, Juan P. Carrizales, Wichor M. Bramer, Saskia Vorstenbosch, Eugene van Puijenbroek, Mieke Hazes, Martijn B.A. van Doorn

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review


Introduction: Information about the possible effects of cutaneous immune-mediated diseases (cIMDs) on male sexual function and reproduction is scarce. Factors known to impair sexual health and reproduction, such as inflammation, medication use, and hypogonadism, can be present in a significant proportion of male patients with cIMD. Objectives: To systematically review the literature for the influence of paternal cIMD on many aspects of male sexual and reproductive health, such as sexual function, reproductive hormones, fertility, and pregnancy and offspring outcomes. Methods: A systematic literature search was performed. The searches combined keywords regarding male sexual function and fertility, pregnancy outcomes, and offspring's health with a list of cIMDs. Results: The majority of the identified studies included patients with psoriasis (22 of 27), and sexual function was the most common outcome of interest (20 of 27). For patients diagnosed with psoriasis, the prevalence of male sexual dysfunction reported in these studies ranged from 34 to 81%. Hypogonadism in patients with psoriasis was reported in 2 of 3 studies. Sperm analysis abnormalities in patients with psoriasis were reported in 3 of 4 studies. No information about the effect of paternal disease on pregnancy and offspring outcomes was identified. Conclusions: Disease activity in psoriasis might play an important role in the development of sexual dysfunction, hypogonadism, and abnormal sperm quality. For the other cIMD included in this review, there is insufficient information regarding male sexual and reproductive health to draw firm conclusions. More research is needed to understand the association between cIMD and impaired male sexual and reproductive health. Perez-Garcia LF, Dolhain R, te Winkel B, et al. Male Sexual Health and Reproduction in Cutaneous Immune-Mediated Diseases: A Systematic Review. Sex Med Rev 2021;9:423–433.

Original languageEnglish
Pages (from-to)423-433
Number of pages11
JournalSexual Medicine Reviews
Issue number3
Publication statusPublished - Jul 2021

Bibliographical note

Funding Information:
This research was funded by three organisations: The Netherlands Organization for Health Research and Development (ZonMw) ( 849200009 ), The Dutch Arthritis Association (ReumaNederland, previously known as Reumafonds) ( 16-3-402 ) and Consejo Nacional de Ciencia y Tecnologia (CONACYT) ( 601574 ). These organisations were not involved in any part of the project, nor in preparing the protocol, nor conducting, analysing, interpreting or publishing the research.

Publisher Copyright:
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