Pharmacogenetic interactions between ABCB1 and SLCO1B1 tagging SNPs and the effectiveness of statins in the prevention of myocardial infarction

BJM Peters, AS Rodin, OH Klungel, Cornelia Duijn, Bruno Stricker, R van 't Slot, A den Boer, AH Zee

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aims: Genetic variability within the SLCO1B1 and ABCB1 transporter genes has been associated with modification of statin effectiveness in cholesterol management. Materials & methods: We conducted a case control study using a population-based registry of pharmacy records linked to the hospital discharge records. Within a hypercholesterolemic cohort, we included 668 myocardial infarction cases and 1217 controls. Results: We tested 24 tagging SNPs and found two SNPs within ABCB1 (rs3789244, p = 0.01; rs1922242, p = 0.01) to interact with statin treatment. In addition, we found a nonsignificant haplotype treatment interaction (p = 0.054). The odds ratio for subjects homozygous for SLCO1B1*1A was 0.49 (95% Cl: 0.34-0.71) compared with 0.31 (95% Cl: 0.24-0.41) for heterozygous or noncarriers of the *1A allele. Conclusion: This is the first study to demonstrate that common genetic variability within the SLCO1B1 and ABCB1 genes is associated with the modification of the effectiveness of statins in the prevention of the clinical outcome, myocardial infarction.
Original languageUndefined/Unknown
Pages (from-to)1065-1076
Number of pages12
JournalPharmacogenomics
Volume11
Issue number8
DOIs
Publication statusPublished - 2010

Cite this