T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment

Alexander Pedroza Gonzalez, Jaap Kwekkeboom, Dave Sprengers

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Recently, we reported the accumulation of CD4+ FOXP3+ regulatory T cells (Tregs) within the tumor mass of patients bearing liver cancer. Tumor-infiltrating Tregs (TiTreg) are active and potent suppressors of antitumor immunity. Importantly, treatment with GITR L reduced the immunosuppression mediated by TiTreg.
Original languageUndefined/Unknown
JournalOncoImmunology
Volume2
Issue number1
DOIs
Publication statusPublished - 2013

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