The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder

Thomas van Doeveren, Alberto Nakauma Gonzalez, AS Mason, Arno van Leenders, Tahlita Zuiverloon, Ellen Zwarthoff, Isabelle Meijssen, Angelique van der Made, AG van der Heijden, K Hendricksen, BWG Rhijn, CS Voskuilen, Job van Riet, Winand Dinjens, Erik jan Dubbink, Harmen van de Werken, Joost Boormans

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2 years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate origins. To investigate the clonal relationship between both entities, we performed targeted DNA sequencing of a panel of 41 genes on matched normal and tumor tissue of 15 primary UTUC patients treated by RNU who later developed 19 UCBs. Based on the detected tumor-specific DNA aberrations, the paired UTUC and UCB(s) of 11 patients (73.3%) showed a clonal relation, whereas in four patients the molecular results did not indicate a clear clonal relationship. Our results support the hypothesis that UCBs following a primary surgically resected UTUC are predominantly clonally derived recurrences and not separate entities.

Original languageEnglish
Pages (from-to)981-987
Number of pages7
JournalInternational Journal of Cancer
Volume148
Issue number4
DOIs
Publication statusPublished - 2021

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