Underdiagnosis of Foodborne Hepatitis A, the Netherlands, 2008-2010

MWF Petrignani, L Verhoef, H Vennema, R van Hunen, D Baas, JE van Steenbergen, Marion Koopmans

Research output: Contribution to journalArticleAcademicpeer-review


Outbreaks of foodborne hepatitis A are rarely recognized as such. Detection of these infections is challenging because of the infection's long incubation period and patients' recall bias. Nevertheless, the complex food market might lead to reemergence of hepatitis A virus outside of disease-endemic areas. To assess the role of food as a source of infection, we combined routine surveillance with real-time strain sequencing in the Netherlands during 2008-2010. Virus RNA from serum of 248 (59%) of 421 reported case-patients could be sequenced. Without typing, foodborne transmission was suspected for only 4% of reported case-patients. With typing, foodborne transmission increased to being the most probable source of infection for 16%. We recommend routine implementation of an enhanced surveillance system that includes prompt forwarding and typing of hepatitis A virus RNA isolated from serum, standard use of questionnaires, data sharing, and centralized interpretation of data.
Original languageUndefined/Unknown
Pages (from-to)596-602
Number of pages7
JournalEmerging Infectious Diseases
Issue number4
Publication statusPublished - 2014

Cite this